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Agili-C™ – Cell-free implant for true hyaline cartilage regeneration

Agili-C™ is an off the shelf, cell-free implant that reproducibly regenerates hyaline cartilage and its underlying subchondral bone in a single-step procedure. Agili-C is CE marked for the treatment of focal articular cartilage and osteochondral defects. In preclinical studies, this innovative and proprietary implant has shown to promote migration, adhesion, proliferation and differentiation of mesenchymal stem cells to simultaneously regenerate both bone and cartilage.

Agili-C is a rigid bi-phasic implant composed of biocompatible and biodegradable FDA approved materials. The bone phase of the implant is composed of calcium carbonate in the aragonite crystalline form, a well-known biomaterial that enhances bone formation. The cartilage phase is a composite of modified aragonite and hyaluronic acid (HA).
Following implantation of Agili-C several biological processes occur:
  • Adhesion, proliferation and differentiation of bone marrow mesenchymal stem cells (MSCs)
  • Bone remodeling by osteoblasts and osteoclasts
  • Invasion and ingrowth of chondrocytes from the periphery in parallel  to MSCs proliferation into chondrocytes
  • Implant biodegradation
Agili-C implantation can be done in an open approach using the unique Agili-Kit™ surgical toolset.
The product is not commercially available in the USA.