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Professionals2017-12-21T13:36:25+00:00

Agili-C™ IDE Clinical Study

The study is designed to compare the efficacy and safety of the Agili-C™ implant to current surgical standard of care treatment, microfracture and debridement, in patients suffering from joint surface lesions of the knee. The patient population involves different kinds of joint surface lesions: focal lesions, osteochondral defects, and mild-to-moderate osteoarthritis, including multiple defects. 

Inclusion Criteria

  1. 21-75 years
  2. Up to 3 treatable joint surface lesions, ICRS Grade IIIa or above, on the femoral condyles or trochlea
  3. Symptomatic total treatable area 1-7 cm2 Asymptomatic lesions will not be included in the calculation
  4. Must be physically & mentally willing and able to comply with the post-operative rehabilitation protocol & scheduled clinical & radiographic visits
  5. Signed and dated the IRB/Ethics Committee approved Informed Consent Form and HIPPA, if applicable
  6. Non-responsive to physical therapy for at least 3-4 weeks

Exclusion Criteria

  1. KOOS Pain subscale score at baseline is less than 20 or more than 65 (scale: maximum pain=0, pain free=100)
  2. Bony defect depth deeper than 8mm, according to baseline MRI/X-ray/arthroscopy
  3. Articular cartilage lesions in the tibia or the patella, ICRS grade IVa or above
  4. Osteoarthritis of the index knee graded 4according to the Kellgren-Lawrence Grading
  5. Significant instability of the index knee according to IKDC Knee Examination Form 2000, Grade C (abnormal) or D (severely abnormal)
  6. Malalignment more than 8 degrees varus OR 8 degrees valgus according to standing X-ray
  7. Lack of functional remaining meniscus, at least 5mm rim, at the end of the procedure
  8. Meniscal transplantation in the past 6 months
  9. Any known tumor of the index knee
  10. Any known history of intra-articular or osseous infection of the index knee
  11. Any evidence of active infection anywhere in the body. Urinary Tract Infection (UTI) patients can be included following antibiotic treatment,
    and provided that two consecutive cultures are negative (taken within at least 2 weeks of each other)
  12. Any known history of inflammatory arthropathy or crystal-deposition arthropathy
  13. Any known systemic cartilage and/or bone disorder, such as, but not limited to, osteoporosis, chondrodysplasia or osteogenesis imperfecta
  14. BMI > 35
  15. Chemotherapy in the past 12 months
  16. Any previous surgical cartilage treatment (such as: microfracture, ACI, OATS, etc.)in the index knee within the last 6 months
  17. Any previous ligamentous repair or malalignment correction in the index knee in the last 6 months
  18. History of allergic reaction or intolerance of materials containing calcium carbonate or hyaluronate
  19. Patient who is pregnant or intends to become pregnant during the study
  20. History of any significant systemic disease, such as, but not limited to, HIV, hepatitis, HTLV, syphilis, and coagulopathies
  21. Known substance or alcohol abuse
  22. Participation in other clinical trials within 60 days prior to the study or concurrent with the study
  23. Known insulin dependent diabetes mellitus
  24. Unable to undergo either MRI or X-ray
  25. Use of anticoagulation medication or antiaggregant medication; however, up to 100 mg Acetylsalicylic acid (ASA) daily is allowed
  26. Previous intra-articular steroid injection within the last 1 month
  27. Prisoners
  28. Uncontained lesion – Lack of vital bone wall, at least 2mm thick, completely surrounding the lesion, based on MRI/X-ray/arthroscopy
  29. Inability to position the implant 2mm recessed relative to the articular surface, based on MRI/X-ray/arthroscopy